Stable isotopes are naturally occurring isotopes that their radioactivity cannot be detected by current techniques. Compared with the tracer technique of radioactive element, stable isotope technique has no radiation damage, and it is not affected by half-life period, which can be applied to long time tracer experiment, and its quantitative test has high accuracy. Since the middle of the 20th century, especially since the 1970s, stable isotope technology has been widely used in the research and production fields of nuclear power industry, medicine, food, agriculture, ecology and geology. At present, 274 kinds of stable isotopes have been discovered, and a few products such as deuterium (2H), carbon-13, nitrogen-15, oxygen-18, neon-22 and boron-10 have been widely used in industrial production. The stable isotope of boron is widely used in biology, medicine, geology and other fields. In the nuclear industry, 10B can be used to produce neutron counters, reactor control rods, and thermal neutron shielding materials. In the medical field, boron neutron capture therapy method is a new radiotherapy method for cancer treatment based on the ability of B10 for capturing thermal neutrons. As a dopant, 11B can be applied in the semiconductor industry, which makes silicon ion layout closely, so that the highly integrated and high-density microchips can be produced. 11B can also be used as an additive to the steel used in the manufacture of reactors, which can greatly improve the resistance to high temperature and radiation.